I am well aware of the blind spots on my car and I set my mirrors accordingly.
Indeed, my car has very thick windscreen pillars that can easily hide a cyclist or motorcyclist. For that reason when at many road junctions I lean forward to check that the road is clear. The rear vision is even worse, from the interior mirror only a small area of the back window is visible, no more than about 20% and coupled with thick rear quarter panels leaves a blind spot thats wider than a motorcycle and rider, right where a motorcyclist would position himself to overtake. I wonder sometimes if drivers and motorcyclists take this into account.